As someone who, until a few years ago, had little experience with firearms, I’ve asked a lot of questions similar to this. Taken a lot of classes, done a lot of training, spent a lot of time at the range. One thing I’d mention, that I hear a lot, is that if you’re going to carry a firearm, keep it loaded and have a round chambered. In the unfortunate event that you’re going to have to pull it out and use it, the average person will forget to chamber a round due to adrenaline, fear, etc. Basically having it ready to be used is your best bet. However, if you’re not comfortable with that, then you should practice drawing it the way you will carry it. I prefer to have a safety on my EDC pistol. So when I go to the range, I fire a couple magazines each visit practicing drawing it from a holster, disabling the safety, and firing it, to build that muscle memory and make it something you don’t have to think about if you’re ever in a situation where you have to draw your weapon. However you choose to carry it, practice it that way. Good luck!