Writing (4)
COVID-19 reinfection is possible, but we don’t know how common it is

Margit Burmeister and Ari Allyn-Feuer both contributed to this report:  If you’ve suffered from COVID-19 and were hoping to get an immunity passport proving you can’t get the virus or spread it ever again, it’s been a bad week for you. This week brought strong clinical evidence that it’s possible for the same person to get COVID-19 twice. Reinfection appears possible, as physicians in two US states have taken to the popular press to tell us. This evidence of reinfection is dishear

2 comments
Does vitamin D protect against COVID-19?

We’ve been reading a lot lately about vitamin D supplementation. Some doctors suspect vitamin D could protect against COVID-19 since vitamin D can also have a positive effect on influenza. Others have suggested that vitamin D deficiency may play a role in the excess of deaths from COVID-19 among people of color in the United States and the United Kingdom. But could vitamin D supplements be the next hydroxychloroquine? While lots of doctors seem to think vitamin D supplements are a good idea

4 comments
How to think about your risk factors for severe illness if you get COVID-19

States may be reopening, but the COVID-19 pandemic is far from over. In fact, some studies show cases are likely to rise, and more than ever Americans are now at risk of contracting COVID-19. Given that everyone's odds of having a run-in with the coronavirus just went up, people are beginning to wonder how much risk they personally face from the disease --- not just risk of death (though that's a valid concern), but the risk of suffering some of the nastier, potentially long-term side effects

10 comments
COVID-19: What to expect if antibody tests are correct

This guest post was written by Margit Burmeister, a Professor of Neuroscience, Genetics, and Computational Medicine and Bioinformatics at the University of Michigan. Last month, one of my former students, Ari Allyn-Feuer, described three possible scenarios of for the ending of the coronavirus pandemic. Like SARS, we might manage to put the virus completely to rest. Therapies and public health could keep it in check until from 150,000 to 7 million people die. What Ari calls "the big burn,"

4 comments

Discussions

I am not usually vaccine hesitant – I have not been vaccinated against the childhood diseases (yeah, I am that old!) but have volunteered to be vaccinated against things most people haven’t heard of like yellow fever and typhus because of travel. But the AstraZeneca/Oxford vaccine has raised many questions for me so I am glad FDA is waiting. First, it showed 62% efficacy with the originally planned scheme, then some people got a different dosing scheme, with LESS vaccine in the first round, and those people were about 80% protected, leading to the media reporting 72% efficacy. I don’t even know if they are now using the lower dose that supposedly was better or the dose that had 62%…  Second, the trial was stopped twice because of a severe neurological reaction – both were considered unrelated. I looked them up. Transverse Myelitis is an inflammation of the spinal cord that can lead to problems walking or temporary paralysis. It is most commonly caused as a rare side effect of vaccinations. And AZ claims that one of the cases happened to get MS around the time of the vaccine…. possible, but together with another case of transverse myelitis has gotten me wonder.  Third, the vector that brings in the DNA is a monkey adenovirus. That virus by itself is not a bad virus but some people are immune to it because they had it. In addition, if you get more than one adenovirus vaccine, your body may learn to recognize adenovirus in addition to what it is supposed to recognize, so any future vaccine then will not work for you because immediately, your body will kill the adenovirus it recognizes. That’s why they use monkey not human. For areas with high HIV, the vaccine against HIV is adenovirus based and there is fear that this cross reaction may cause problems with HIV vaccinations later – as expressed in a Lancet article. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32156-5/fulltext Forth, the link you gave to VOX also states that AZ was not open about their research. Exactly.  If this is the only vaccine available and given the severity of COVID-19, I would say fine, still better than getting COVID – and it may be the only option for developing countries without a solid cold chain, and may still bring down the virus enough for the population. But it wouldn’t be my first choice when we have more effective vaccines. For drugs to get approved, you need to show its better than what we already have – and I don’t see why in April the Oxford/AZ vaccine should be approved given we have BioNtech/Pfizer and Moderna

I am not usually vaccine hesitant – I have not been vaccinated against the childhood diseases (yeah, I am that old!) but have volunteered to be vaccinated against things most people haven’t heard of like yellow fever and typhus because of travel. But the AstraZeneca/Oxford vaccine has raised many questions for me so I am glad FDA is waiting. First, it showed 62% efficacy with the originally planned scheme, then some people got a different dosing scheme, with LESS vaccine in the first round, and those people were about 80% protected, leading to the media reporting 72% efficacy. I don’t even know if they are now using the lower dose that supposedly was better or the dose that had 62%…  Second, the trial was stopped twice because of a severe neurological reaction – both were considered unrelated. I looked them up. Transverse Myelitis is an inflammation of the spinal cord that can lead to problems walking or temporary paralysis. It is most commonly caused as a rare side effect of vaccinations. And AZ claims that one of the cases happened to get MS around the time of the vaccine…. possible, but together with another case of transverse myelitis has gotten me wonder.  Third, the vector that brings in the DNA is a monkey adenovirus. That virus by itself is not a bad virus but some people are immune to it because they had it. In addition, if you get more than one adenovirus vaccine, your body may learn to recognize adenovirus in addition to what it is supposed to recognize, so any future vaccine then will not work for you because immediately, your body will kill the adenovirus it recognizes. That’s why they use monkey not human. For areas with high HIV, the vaccine against HIV is adenovirus based and there is fear that this cross reaction may cause problems with HIV vaccinations later – as expressed in a Lancet article. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32156-5/fulltext Forth, the link you gave to VOX also states that AZ was not open about their research. Exactly.  If this is the only vaccine available and given the severity of COVID-19, I would say fine, still better than getting COVID – and it may be the only option for developing countries without a solid cold chain, and may still bring down the virus enough for the population. But it wouldn’t be my first choice when we have more effective vaccines. For drugs to get approved, you need to show its better than what we already have – and I don’t see why in April the Oxford/AZ vaccine should be approved given we have BioNtech/Pfizer and Moderna