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Tapentadol is a prescription medication primarily used for the management of moderate to severe acute pain. It is an opioid analgesic with both mu-opioid receptor agonist activity and norepinephrine reuptake inhibition properties. Tapentadol is prescribed for the relief of moderate to severe acute pain, such as pain following surgery, injury, or medical procedures. It may also be used for certain chronic pain conditions, such as neuropathic pain associated with diabetic peripheral neuropathy (DPN) when other treatments have not provided adequate relief.